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Persistence of Candida sp. 115 during hydrolysis of penicillin G and metabolism of phenylacetic acid.

Deshpande, B S; Ambedkar, S S; Sudhakaran, V K; Narayanan, R A; Shewale, J G.

Hindustan Antibiot Bull ; 1989 Aug-Nov; 31(3-4): 71-5

Article in English | IMSEAR | ID: sea-2293

ABSTRACT

The growth of Candida sp. 115 was investigated on the constituents of penicillin G hydrolysis reaction mixture. Neither penicillin G nor 6-aminopenicillanic acid was degraded or utilised for growth. The yeast accepted phenylacetic acid, sodium acetate and glucose as growth substrates. Phenylacetic acid was metabolised via p-hydroxy phenylacetic acid, which was the only accumulated metabolite. The enzymes responsible for hydroxylation of phenylacetic acid were induced by phenylacetic acid and sodium acetate.

Subject(s)

Acetic Acid , Acetates/metabolism , Candida/growth & development , Culture Media , Glucose/metabolism , Hydrolysis , Penicillin G/metabolism , Phenylacetates/metabolism

Utilization of glucose and phosphate by fungus Aspergillus ochraceus during submerged fermentation and its relationship to the production of anti-viral substance 6-MFA.

Narayanan, R A; Shinde, Y P; Dhuley, J N; Padwal, G B; Borkar, P S; Naik, S R.

Hindustan Antibiot Bull ; 1986 Feb-Nov; 28(1-4): 1-4

Article in English | IMSEAR | ID: sea-2533

Subject(s)

Antiviral Agents , Aspergillus/metabolism , Aspergillus ochraceus/metabolism , Fermentation , Fungal Proteins/biosynthesis , Glucose/metabolism , Phosphates/metabolism

Newer approaches for improving Streptomyces strains. I. Studies on protoplast fusion of S. griseus.

Kolhekar, S; Narayanan, R A; Borkar, P S.

Hindustan Antibiot Bull ; 1986 Feb-Nov; 28(1-4): 42-3

Article in English | IMSEAR | ID: sea-2212

Subject(s)

Protoplasts , Streptomyces griseus/genetics

Fermentation: process and production 4.

Subrahmanyam, A; Narayanan, R A.

Hindustan Antibiot Bull ; 1984 Aug-Nov; 26(3-4): 145-58

Article in English | IMSEAR | ID: sea-2515

Subject(s)

Enzymes/biosynthesis , Fermentation , Fungi/enzymology

In vitro activity of chloramphenicol against drug resistant strains of Mycobacterium tuberculosis.

Narayanan, R A.

Hindustan Antibiot Bull ; 1984 Aug-Nov; 26(3-4): 102-4

Article in English | IMSEAR | ID: sea-2146

Subject(s)

Chloramphenicol/pharmacology , Drug Resistance, Microbial , Microbial Sensitivity Tests , Mycobacterium tuberculosis/drug effects

Fermentation: process and products. 2. Pseudomonads.

Narayanan, R A; Subrahmanyam, A.

Hindustan Antibiot Bull ; 1984 Feb-May; 26(1-2): 46-55

Article in English | IMSEAR | ID: sea-2517

Subject(s)

Biological Products/biosynthesis , Fermentation , Pseudomonas/metabolism

Fermentation--processes and products.

Subrahmanyam, A; Narayanan, R A; Saroj, C.

Hindustan Antibiot Bull ; 1984 Feb-May; 26(1-2): 43-5

Article in English | IMSEAR | ID: sea-2392

Subject(s)

Biological Products/biosynthesis , Fermentation , Microbiology

Reduction of drug resistance of mycobacterium tuberculosis after treatment with hamycin.

Panse, M V; Narayanan, R A; Sathe, P M.

Article in English | IMSEAR | ID: sea-18367

Subject(s)

Adolescent , Adult , Antitubercular Agents/pharmacology , Drug Resistance, Microbial , Female , Humans , Lung Diseases, Fungal/complications , Male , Microbial Sensitivity Tests , Middle Aged , Mycobacterium tuberculosis/drug effects , Natamycin/pharmacology , Tuberculosis, Pulmonary/complications

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